ANTIMICROBIAL AGENTS AND CHEMOTHERAPY - 2017/8

Module code: MMIM031

Module provider

School of Biosciences and Medicine

Module Leader

COTTELL A Dr (Biosc & Med)

Number of Credits

15

ECT Credits

7.5

Framework

FHEQ Level 7

JACs code

C521

Module cap (Maximum number of students)

N/A

Module Availability

Semester 1

Overall student workload

Workshop Hours: 3

Independent Study Hours: 120

Lecture Hours: 27

Assessment pattern

Assessment type Unit of assessment Weighting
Coursework DATA ANALYSIS / CASE STUDY EXERCISE 30
Examination EXAM (TWO HOURS; FOUR QUESTIONS FROM A CHOICE OF SIX) 70

Alternative Assessment

N/A

Prerequisites / Co-requisites

N/A

Module overview

This module deals with antimicrobial agents and chemotherapy. The molecular basis for the action of antibiotics, antiprotozoal, and antifungal drugs are covered together with the basis for resistance to these agents. Principles of pharmacology will be investigated, together with prescribing practices. Specific pathogens associated with a high level of drug tolerance and resistance are covered in detail. (N.B. Viruses are covered in a separate module).

Module aims

• Cover the molecular basis for the action of antimicrobial drugs together with the molecular basis for tolerance and resistance to these agents

• Study specific pathogens that are associated with antibiotic resistance

• Describe methods used to measure and evaluate antimicrobial sensitivity

• Enable understanding of the interaction between host, pathogen, and drug, as defined by pharmacokinetics and pharmacodynamics.

• Explain and discuss antimicrobial prescribing policies with reference to the different spectra of antimicrobials, and strategies to control antimicrobial use in order to minimise the development of resistance

• Consider new approaches to the treatment of infectious disease

Learning outcomes

Attributes Developed
• Describe the action and resistance of the major groups of antimicrobial agents, with reference to specific named examples KC
• Explain why antimicrobial resistance with reference to specific microbes KC
• Discuss and evaluate laboratory methods for measuring antimicrobial sensitivity KCPT
• Understand principles of pharmacokinetics and pharmacodynamics KC
• Critically evaluate how prescribing policies are developed to control usage of antimicrobials KC
• Evaluate processes by which new antimicrobials are developed and tested KC

Attributes Developed

C - Cognitive/analytical

K - Subject knowledge

T - Transferable skills

P - Professional/Practical skills

Module content

Indicative content includes:


General concepts of antimicrobial action and resistance
Selective toxicity
Mechanisms of antibiotic action: cell wall inhibitors; inhibitors of ribosome function; antifolates; nucleic acid synthesis inhibitors; antifungal agents; antiprotozoal agents
Biochemistry and genetics of resistance: intrinsic and acquired resistance; plasmids, transposons and mutations; multiple drug resistance; efflux pumps
Pharmacological aspects
Recent developments in methods used to measure antimicrobial sensitivity
Effect of sub-lethal levels
Combinations of antibiotics: synergy and antagonism
Use of antibiotics: antibiotic policy and chemoprophylaxis
Antibiotic production and discovery
Examples of notable antimicrobial-resistant microbes such as MRSA; Pseudomonas aeruginosa; Plasmodium spp.

Methods of Teaching / Learning

The learning and teaching strategy is designed to:

Consolidate fundamental concepts of antimicrobial chemotherapy by inviting specialist experts to give lectures. A deep understanding of the subject is fostered by the data analysis exercise.

The learning and teaching methods include:


This module is primarily delivered as a lecture programme (approximately 23 hours), complemented with problem-solving and data analysis exercises ; class discussions (3 h), and laboratory practical classes  (4 h).

Assessment Strategy

The assessment strategy is designed to provide students with the opportunity to demonstrate


Knowledge and understanding of the action and resistance of the major groups of antimicrobial agents, with reference to specific named examples
Ability to describe antimicrobial resistance in specific microbes
Ability to describe and evaluate laboratory methods for measuring antimicrobial sensitivity
A sound understanding of principles of pharmacokinetics and pharmacodynamics
Ability to critically evaluate how prescribing policies are developed to control usage of antimicrobials
Knowledge and understanding of the way in which new antimicrobials are developed and tested
Thus, the summative assessment for this module consists of:

Data analysis / case study exercise (to be submitted in week 11)
Two-hour exam: four answers from  a choice of six questions)


Formative assessment and feedback

Formative assessment is integral to this module and will be provided in lectures by using questions and discussions throughout.  This module also includes a data analysis session. Self-tests and other exercises will be available, for which feedback will be provided on SurreyLearn..

Students received verbal feedback during lectures and during the data analysis session. Finally feedback is provided by extensive annotation of exam papers and an open-door afternoon post-exam to look at marked papers with students.

 

 

Reading list

Reading list for ANTIMICROBIAL AGENTS AND CHEMOTHERAPY : http://aspire.surrey.ac.uk/modules/mmim031

Programmes this module appears in

Programme Semester Classification Qualifying conditions
Medical Microbiology (EuroMasters) MSc 1 Compulsory A weighted aggregate mark of 50% is required to pass the module
Medical Microbiology MSc 1 Compulsory A weighted aggregate mark of 50% is required to pass the module

Please note that the information detailed within this record is accurate at the time of publishing and may be subject to change. This record contains information for the most up to date version of the programme / module for the 2017/8 academic year.