Module code: APTM005

Module provider

School of Biosciences and Medicine

Module Leader

BAILEY I Dr (Biosc & Med)

Number of Credits: 15

ECTS Credits: 7.5

Framework: FHEQ Level 7

JACs code: B220

Module cap (Maximum number of students): N/A

Module Availability

Semester 1

Module content

• Structure and functions
• Xenobiotic metabolism
• Acute pathological changes
• Mechanisms of acute hepatotoxicity
• Adaptive and toxic changes in the liver of rodents
• Chronic hepatotoxicity, repair, cirrhosis
• Hepatocarcinogenesis
• Assessment of hepatic function and damage in animal species
• Cholestasis

• Structure
• Regulation of secretions
• NSAIDS and ulcer formation
• The rodent forestomach
• Toxicology of the caecum
• Acute and chronic toxicity of the glandular stomach and intestines
• Hypersensitivity, Peyer's patches and the gastric immune system
• Carcinogenesis in the glandular stomach and intestine
• Carcinogenesis in the pancreas

• Structure of the mammalian kidney
• Functions of the mammalian kidney
• Assessment of renal function and damage in animal species
• Nephrotoxins I - the tubule
• Nephrotoxins II - glomerulus and papilla
• Secondary effects of kidney failure

• Normal skin structure and function
• Absorption of compounds into and across skin
• Chemically-induced skin damage, irritation and repair
• Sensitisation and hypersensitivity reactions
• UV-induced skin damage and photosensitisation.

Assessment pattern

Assessment type Unit of assessment Weighting
Coursework COURSEWORK 100

Alternative Assessment


Assessment Strategy

The assessment strategy is designed to provide students with the opportunity to demonstrate

advanced knowledge and critical evaluation of issues arising in clinical trials and in good clinical practice
skills in the application of knowledge, in self-direction and originality in tackling and solving problems in line with the learning outcomes


Thus, the summative assessment for this module consists of:

2,000 word home assignment


Formative assessment and feedback

Class discussion
Module feedback session during module delivery

Module aims

Learning outcomes

Attributes Developed
001 Have a basic understanding of the physiology and anatomy of the liver, kidney, gastrointestinal tract and skin K
002 Understand the basis for the major toxicities described for compounds that affect the liver, kidneys, gastrointestinal tract and skin K
003 Understand the basic pathological and biochemical changes associated with such toxicity K
004 Be able to integrate the significance of liver, kidney, gastrointestinal tract and skin toxicity observed in animal testing in the context of human risk assessment K
005 Be able to identify the major testing strategies for examining toxicity to the liver, kidneys, gastrointestinal tract or skin K

Attributes Developed

C - Cognitive/analytical

K - Subject knowledge

T - Transferable skills

P - Professional/Practical skills

Overall student workload

Independent Study Hours: 120

Lecture Hours: 30

Methods of Teaching / Learning

Indicated Lecture Hours (which may also include seminars, tutorials, workshops and other contact time) are approximate and may include in-class tests where one or more of these are an assessment on the module. In-class tests are scheduled/organised separately to taught content and will be published on to student personal timetables, where they apply to taken modules, as soon as they are finalised by central administration. This will usually be after the initial publication of the teaching timetable for the relevant semester.

Reading list


Please note that the information detailed within this record is accurate at the time of publishing and may be subject to change. This record contains information for the most up to date version of the programme / module for the 2018/9 academic year.