MOLECULAR BIOLOGY AND GENETICS: FROM GENES TO BIOLOGICAL FUNCTION - 2022/3
Module code: BMS2036
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The purpose of this module is to introduce to the students the ways in which biological function is controlled through control of gene expression at different levels. This module will help the students to both acquire core theoretical core knowledge and key practical skills.
School of Biosciences and Medicine
ASIM Mohammad (Biosc & Med)
Number of Credits: 15
ECTS Credits: 7.5
Framework: FHEQ Level 5
JACs code: C700
Module cap (Maximum number of students): N/A
Prerequisites / Co-requisites
Indicative content includes:
Model organisms and their genomes
The human genome
Isolating and sequencing single genes
Whole-genome and whole-exome sequencing
Gene therapy and CRISPR
DNA repair and recombination
The genetic basis of cancer
Deregulation of the cell cycle and genome maintenance pathways in cancer
Overview of eukaryotic gene control, RNA poly II promoters and general TFs
Cis-regions and transcription factors, molecular mechanisms of repression and activation
Regulation of translation factor activity, other transcription systems
RNA processing in the nucleus
Life and death of RNA in the cytoplasm
Molecular mechanisms of translation
Regulation of transcription factor activity
Global regulation of translation
Gene expression profiling
Epigenetic regulation of transcription
|Assessment type||Unit of assessment||Weighting|
|Examination||50 MCQ and 2 out of 7 essay-type questions (2 hours)||70|
If practical components require re-assessment there will be a written exam to assess the underlying principles of the appropriate learning outcomes. This will reflect the material covered in the original assessment and will carry the same weighting.
The assessment strategy is designed to provide students with the opportunity to demonstrate understanding of the topic, and ability to find, evaluate and use material to answer the coursework questions.
Thus, the summative assessment for this module consists of:
- Coursework: Practical write-up. Submission deadline 2 weeks after last practical session. Provisional deadlines will be Tuesday week 11 (group 1). Tuesday week 13 (group 2), and Tuesday week 15 (group 3)
- Examination (2 hours): 50 MCQ and 2 essay-type questions
Formative assessment and feedback
General feedback about practicals and lectures is provided in the form of feedback tutorials and at the end of practicals sessions for each group. Also, feedback is provided via SurreyLearn through the discussion tool.
- Advance the student's understanding of the inheritance and function of genes, and some of the major methodologies applied to their study, especially in relation to eukaryotes and in particular our own species.
- The origins and nature of genetic variation
- Methods for studying genomes and transcriptomes
- Genomic manipulation
- The genetic basis of cancer
- Eukaryotic gene control
- The process of transcription and its regulation
- Epitnetic mechanisms
- Laboratory analysis of gene expression
- Introduce the student to basic molecular biology techniques.
|001||Know and understand the essential elements of the process of gene expression from DNA to biological function, and how it is regulated||KC|
|002||Understand the concept of genetic variability and how it relates to phenotypic variability||C|
|003||Grasp the basic concepts and techniques for genomic and transcriptomic analysis||KC|
|004||Appreciate the basic principles and applications of animal transgenesis and of gene therapy||KC|
|005||Be able to perform and interpret basic molecular biology procedures||PT|
|006||Appreciate the theoretical basis of the above methods||KC|
|007||Have a basic knowledge and understanding of the genetic basis of cancer||KC|
C - Cognitive/analytical
K - Subject knowledge
T - Transferable skills
P - Professional/Practical skills
Overall student workload
Independent Study Hours: 109
Lecture Hours: 32
Laboratory Hours: 9
Methods of Teaching / Learning
The learning and teaching strategy is designed to:
Provide the basic information to understand the principles and concepts of gene organisation and expression, and methods and approaches employed in cloning genes and stuying their expression, and help the students to acquire hands on experimental skills. Methods and approaches will be taught specifically in the context of the theory (e g in the form of case studies).
The learning and teaching methods include:
Lectures (30 hours), tutorials (5 hours)
Lab practical sessions (9 hours over two weeks)
Indicated Lecture Hours (which may also include seminars, tutorials, workshops and other contact time) are approximate and may include in-class tests where one or more of these are an assessment on the module. In-class tests are scheduled/organised separately to taught content and will be published on to student personal timetables, where they apply to taken modules, as soon as they are finalised by central administration. This will usually be after the initial publication of the teaching timetable for the relevant semester.
Upon accessing the reading list, please search for the module using the module code: BMS2036
Programmes this module appears in
|Microbiology BSc (Hons)||1||Optional||A weighted aggregate mark of 40% is required to pass the module|
|Biomedical Science BSc (Hons)||1||Compulsory||A weighted aggregate mark of 40% is required to pass the module|
|Veterinary Biosciences BSc (Hons)||1||Compulsory||A weighted aggregate mark of 40% is required to pass the module|
|Biological Sciences BSc (Hons)||1||Compulsory||A weighted aggregate mark of 40% is required to pass the module|
|Biomedical Science MSci (Hons)||1||Compulsory||A weighted aggregate mark of 40% is required to pass the module|
|Biochemistry BSc (Hons)||1||Compulsory||A weighted aggregate mark of 40% is required to pass the module|
|Biochemistry MSci (Hons)||1||Compulsory||A weighted aggregate mark of 40% is required to pass the module|
Please note that the information detailed within this record is accurate at the time of publishing and may be subject to change. This record contains information for the most up to date version of the programme / module for the 2022/3 academic year.