CANCER - PATHOGENESIS AND THERAPEUTICS - 2022/3
Module code: BMS3063
In light of the Covid-19 pandemic, and in a departure from previous academic years and previously published information, the University has had to change the delivery (and in some cases the content) of its programmes, together with certain University services and facilities for the academic year 2020/21.
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Gives the student a broad understanding of the problem and biological processes underlying cancer and a range of clinically relevant therapeutic approaches. The emphasis is on human studies and data and it fits well within a biomedical sciences program
School of Biosciences and Medicine
MEIRA Lisiane (Biosc & Med)
Number of Credits: 15
ECTS Credits: 7.5
Framework: FHEQ Level 6
JACs code: B130
Module cap (Maximum number of students): N/A
Prerequisites / Co-requisites
BMS2036 - MOLECULAR BIOLOGY AND GENETICS: FROM GENES TO BIOLOGICAL FUNCTION
Introduction to cancer,: causes, epidemiology, lifestyle + environment
Histopathology of cancer: classification of cancer lesions, the pathologist’s perspective
Development of cancer: from cancer initiation to disease progression and metastases
Molecular processes underlying cancer: cancer hallmarks, oncogenic changes working singly and in parallel
DNA damage and repair: mismatches and mutations, DNA repair in cancer development and cancer treatment, cancer prone syndromes
Viruses and genetic factors: virally induced cancers, familial cancers, common genetic defects in cancer
Common cancers: breast, colon and lung cancer:; incidence, disease presentation, associated genetics, risk factors
Cancer therapy: conventional cancer chemotherapy drugs: main classes, mechanisms of action, toxicities, tumour types treated
Drug resistance: the clinical problem and underlying mechanisms
New targeted therapy for cancer: growth factor receptors, oncogene targets, anti-angiogenics, new developments
Immunotherapy: cancer treatment in the 21st century
Clinical Case study: real cancer patient cases, presentation and subsequent treatment pathways
|Assessment type||Unit of assessment||Weighting|
|Coursework||1 X 1500 WORD ESSAY FROM A CHOICE OF TOPICS||30|
|Examination||2 x 1-HOUR EXTENDED ESSAYS, STUDENTS TO ANSWER 2 QUESTIONS FROM A CHOICE OF 5||70|
The assessment strategy is designed to provide students with the opportunity to demonstrate:
- Extended reading and analysis of relevant material: Coursework essay is based on topics that are related to but not directly covered in the lecture series.
- Engagement in the use of feedback: there will be opportunity for peer feedback sessions prior to coursework submission.
- Engagement in the use of feedback II: there will be one coursework tutorial where guidance will be given to students about coursework format and assessment criteria.
- A depth of understanding and integration of knowledge about molecular mechanisms, cancer pathogenesis and therapeutic approaches in a 2 hour extended examination essay (2 questions answered from a choice of 5).
Thus, the summative assessment for this module consists of:
- 1 coursework essay from a choice of 3 topics, 1500 words.
- 2-hour examination in which students write 2 extended essays from a choice of 5 questions.
Formative assessment and feedback
- Individual tutoring on the coursework preparation and the reasons for the marking is provided on request.
- Coursework is given back with comments and general points are covered in short tutorial-type periods before lectures.
- Provide an understanding of the factors responsible for the development of the most common forms of cancer and students will have an appreciation of the development of cancers both from a molecular viewpoint and also from early precancerous lesions to terminal disease from the viewpoint of histopathology.
- To provide an understanding of how genetics, environmental and stochastic factors contribute to the development of human cancers.
- Demonstrate how we can interfere with the development of cancers in a chemo-preventative setting, by the use of chemotherapeutic agents and also gain an understanding into the development and use of new therapies based on rational design and immunotherapy.
|1||Understand the factors responsible for the development of the most common forms of cancer||KT|
|2||Appreciation of the development of cancers from early precancerous lesions to terminal disease from the viewpoint of histopathology||KT|
|3||Understand how one can interfere with the development of cancers both in a chemo-preventative setting and also by the use of chemotherapeutic agents||KCT|
|4||Gain an understanding into the development and use of new targeted therapies based on rational design||KCPT|
C - Cognitive/analytical
K - Subject knowledge
T - Transferable skills
P - Professional/Practical skills
Overall student workload
Independent Study Hours: 122
Lecture Hours: 24
Tutorial Hours: 2
Practical/Performance Hours: 2
Methods of Teaching / Learning
The learning and teaching strategy is designed to:
- Provide lectures delivered by research active experts in the field of cancer research including clinical oncologists.
- Allow integration of knowledge of molecular mechanisms and disease pathogenesis of a variety of cancer types.
- Introduce the students to concepts of therapeutic strategy and design within the context of cancer pathogenesis.
The learning and teaching methods include:
- Lectures given over a 10-12 week period amounting to 24 hours
- One clinical study lecture given by a medical oncologist
- Sessions for advice on scientific writing and the correct use of referencing (for coursework)
- Session for coursework peer-review
- A revision tutorial
Indicated Lecture Hours (which may also include seminars, tutorials, workshops and other contact time) are approximate and may include in-class tests where one or more of these are an assessment on the module. In-class tests are scheduled/organised separately to taught content and will be published on to student personal timetables, where they apply to taken modules, as soon as they are finalised by central administration. This will usually be after the initial publication of the teaching timetable for the relevant semester.
Upon accessing the reading list, please search for the module using the module code: BMS3063
Programmes this module appears in
|Microbiology BSc (Hons)||2||Optional||A weighted aggregate mark of 40% is required to pass the module|
|Biomedical Science BSc (Hons)||2||Compulsory||A weighted aggregate mark of 40% is required to pass the module|
|Biological Sciences BSc (Hons)||2||Optional||A weighted aggregate mark of 40% is required to pass the module|
|Biomedical Science MSci (Hons)||2||Compulsory||A weighted aggregate mark of 40% is required to pass the module|
|Biochemistry BSc (Hons)||2||Optional||A weighted aggregate mark of 40% is required to pass the module|
|Biochemistry MSci (Hons)||2||Optional||A weighted aggregate mark of 40% is required to pass the module|
Please note that the information detailed within this record is accurate at the time of publishing and may be subject to change. This record contains information for the most up to date version of the programme / module for the 2022/3 academic year.