ANTIMICROBIAL AGENTS AND CHEMOTHERAPY - 2022/3
Module code: MMIM031
In light of the Covid-19 pandemic the University has revised its courses to incorporate the ‘Hybrid Learning Experience’ in a departure from previous academic years and previously published information. The University has changed the delivery (and in some cases the content) of its programmes. Further information on the general principles of hybrid learning can be found at: Hybrid learning experience | University of Surrey.
We have updated key module information regarding the pattern of assessment and overall student workload to inform student module choices. We are currently working on bringing remaining published information up to date to reflect current practice during the academic year 2021/22.
This means that some information within the programme and module catalogue will be subject to change. Current students are invited to contact their Programme Leader or Academic Hive with any questions relating to the information available.
This module deals with antimicrobial agents and chemotherapy. The molecular basis for the action of antibiotics, antiprotozoal, and antifungal drugs are covered together with the basis for resistance to these agents. Principles of pharmacology will be investigated, together with prescribing practices. Specific pathogens associated with a high level of drug tolerance and resistance are covered in detail. (N.B. Viruses are covered in a separate module).
School of Biosciences and Medicine
COTTELL Alison (Biosc & Med)
Number of Credits: 15
ECTS Credits: 7.5
Framework: FHEQ Level 7
JACs code: C510
Module cap (Maximum number of students): N/A
Overall student workload
Workshop Hours: 5
Independent Learning Hours: 119
Lecture Hours: 22
Tutorial Hours: 4
Prerequisites / Co-requisites
Indicative content includes:
- General concepts of antimicrobial action and resistance / tolerance / persistence
- Selective toxicity
- Mechanisms of antibiotic action: cell wall inhibitors; inhibitors of ribosome function; antifolates; nucleic acid synthesis inhibitors; antifungal agents; antiprotozoal agents; antiviral agents
- Biochemistry and genetics of resistance: intrinsic and acquired resistance; plasmids, transposons and mutations; multiple drug resistance; efflux pumps
- Pharmacological aspects
- Recent developments in methods used to measure antimicrobial sensitivity
- Effect of sub-lethal levels
- Combinations of antibiotics: synergy and antagonism
- Use of antibiotics: antibiotic policy and chemoprophylaxis
- Antibiotic production and discovery
- Examples of notable antimicrobial-resistant microbes such as MRSA; Pseudomonas aeruginosa; Plasmodium spp.; HIV
|Assessment type||Unit of assessment||Weighting|
|Coursework||Grant proposal investigation - expanding our understanding of antimicrobials||100|
The assessment strategy is designed to provide students with the opportunity to demonstrate
- Knowledge and understanding of the action and resistance of the major groups of antimicrobial agents, with reference to specific named examples
- Ability to describe antimicrobial resistance in specific microbes
- Ability to describe and evaluate laboratory methods for measuring antimicrobial sensitivity
- Knowledge and understanding of the way in which new antimicrobials are developed and tested
Thus, the summative assessment for this module consists of:
- Grant proposal application - furthering our understanding of antimicrobial drugs
Formative assessment and feedback
Formative assessment is integral to this module and will be provided through mid-semester 1:1 feedback on grant proposal progress.
- Cover the molecular basis for the action of antimicrobial drugs together with the molecular basis for tolerance, persistence, and resistance to these agents
- Study specific pathogens that are associated with antimicrobial resistance
- Describe methods used to measure and evaluate antimicrobial sensitivity
- Enable understanding of the interaction between host, pathogen, and drug.
- Explain and discuss antimicrobial prescribing policies with reference to the different spectra of antimicrobials, and strategies to control antimicrobial use in order to minimise the development of resistance
- Consider new approaches to the treatment of infectious disease
|001||Describe the action and resistance of the major groups of antimicrobial agents, with reference to specific named examples||KC|
|002||Explain why antimicrobial resistance with reference to specific microbes||KC|
|003||Discuss and evaluate laboratory methods for measuring antimicrobial sensitivity||KC|
|004||Understand principles of resistance, tolerance, and persistence||KC|
|005||Critically evaluate how prescribing policies are developed to control usage of antimicrobials||KC|
|006||Evaluate processes by which new antimicrobials are developed and tested||KC|
C - Cognitive/analytical
K - Subject knowledge
T - Transferable skills
P - Professional/Practical skills
Methods of Teaching / Learning
The learning and teaching strategy is designed to:
Consolidate fundamental concepts of antimicrobial chemotherapy by inviting specialist experts to give lectures. A deep understanding of the subject is fostered by the data analysis exercise.
The learning and teaching methods include:
- This module is primarily delivered as a lecture programme (approximately 12 hours), complemented with problem-solving and data analysis exercises (5 h) and laboratory practical classes (6 h).
Indicated Lecture Hours (which may also include seminars, tutorials, workshops and other contact time) are approximate and may include in-class tests where one or more of these are an assessment on the module. In-class tests are scheduled/organised separately to taught content and will be published on to student personal timetables, where they apply to taken modules, as soon as they are finalised by central administration. This will usually be after the initial publication of the teaching timetable for the relevant semester.
Upon accessing the reading list, please search for the module using the module code: MMIM031
Please note that the information detailed within this record is accurate at the time of publishing and may be subject to change. This record contains information for the most up to date version of the programme / module for the 2022/3 academic year.