ANTIMICROBIAL AGENTS AND CHEMOTHERAPY - 2019/0
Module code: MMIM031
This module deals with antimicrobial agents and chemotherapy. The molecular basis for the action of antibiotics, antiprotozoal, and antifungal drugs are covered together with the basis for resistance to these agents. Principles of pharmacology will be investigated, together with prescribing practices. Specific pathogens associated with a high level of drug tolerance and resistance are covered in detail. (N.B. Viruses are covered in a separate module).
School of Biosciences and Medicine
COTTELL Alison (Biosc & Med)
Number of Credits: 15
ECTS Credits: 7.5
Framework: FHEQ Level 7
JACs code: C510
Module cap (Maximum number of students): N/A
Overall student workload
Workshop Hours: 3
Independent Learning Hours: 120
Lecture Hours: 27
Prerequisites / Co-requisites
Indicative content includes:
- General concepts of antimicrobial action and resistance
- Selective toxicity
- Mechanisms of antibiotic action: cell wall inhibitors; inhibitors of ribosome function; antifolates; nucleic acid synthesis inhibitors; antifungal agents; antiprotozoal agents
- Biochemistry and genetics of resistance: intrinsic and acquired resistance; plasmids, transposons and mutations; multiple drug resistance; efflux pumps
- Pharmacological aspects
- Recent developments in methods used to measure antimicrobial sensitivity
- Effect of sub-lethal levels
- Combinations of antibiotics: synergy and antagonism
- Use of antibiotics: antibiotic policy and chemoprophylaxis
- Antibiotic production and discovery
- Examples of notable antimicrobial-resistant microbes such as MRSA; Pseudomonas aeruginosa; Plasmodium spp.
|Assessment type||Unit of assessment||Weighting|
|Coursework||ESSAY / CASE STUDY EXERCISE||30|
|Examination||EXAM (TWO HOURS) (FOUR QUESTIONS FROM A CHOICE OF SIX)||70|
The assessment strategy is designed to provide students with the opportunity to demonstrate
- Knowledge and understanding of the action and resistance of the major groups of antimicrobial agents, with reference to specific named examples
- Ability to describe antimicrobial resistance in specific microbes
- Ability to describe and evaluate laboratory methods for measuring antimicrobial sensitivity
- A sound understanding of principles of pharmacokinetics and pharmacodynamics
- Ability to critically evaluate how prescribing policies are developed to control usage of antimicrobials
- Knowledge and understanding of the way in which new antimicrobials are developed and tested
Thus, the summative assessment for this module consists of:
- Essay / case study exercise (to be submitted in week 11)
- Two-hour exam: four answers from a choice of six questions)
Formative assessment and feedback
Formative assessment is integral to this module and will be provided in lectures by using questions and discussions throughout.
Students received verbal feedback during lectures. Finally feedback is provided by extensive annotation of exam papers and an open-door afternoon post-exam to look at marked papers with students.
- • Cover the molecular basis for the action of antimicrobial drugs together with the molecular basis for tolerance and resistance to these agents
- • Study specific pathogens that are associated with antibiotic resistance
- • Describe methods used to measure and evaluate antimicrobial sensitivity
- • Enable understanding of the interaction between host, pathogen, and drug, as defined by pharmacokinetics and pharmacodynamics.
- • Explain and discuss antimicrobial prescribing policies with reference to the different spectra of antimicrobials, and strategies to control antimicrobial use in order to minimise the development of resistance
- • Consider new approaches to the treatment of infectious disease
|001||Describe the action and resistance of the major groups of antimicrobial agents, with reference to specific named examples||KC|
|002||Explain why antimicrobial resistance with reference to specific microbes||KC|
|003||Discuss and evaluate laboratory methods for measuring antimicrobial sensitivity||KC|
|004||Understand principles of pharmacokinetics and pharmacodynamics||KC|
|005||Critically evaluate how prescribing policies are developed to control usage of antimicrobials||KC|
|006||Evaluate processes by which new antimicrobials are developed and tested||KC|
C - Cognitive/analytical
K - Subject knowledge
T - Transferable skills
P - Professional/Practical skills
Methods of Teaching / Learning
The learning and teaching strategy is designed to:
Consolidate fundamental concepts of antimicrobial chemotherapy by inviting specialist experts to give lectures. A deep understanding of the subject is fostered by the data analysis exercise.
The learning and teaching methods include:
- This module is primarily delivered as a lecture programme (approximately 23 hours), complemented with problem-solving and data analysis exercises ; class discussions (3 h), and laboratory practical classes (4 h).
Indicated Lecture Hours (which may also include seminars, tutorials, workshops and other contact time) are approximate and may include in-class tests where one or more of these are an assessment on the module. In-class tests are scheduled/organised separately to taught content and will be published on to student personal timetables, where they apply to taken modules, as soon as they are finalised by central administration. This will usually be after the initial publication of the teaching timetable for the relevant semester.
Upon accessing the reading list, please search for the module using the module code: MMIM031
Programmes this module appears in
Please note that the information detailed within this record is accurate at the time of publishing and may be subject to change. This record contains information for the most up to date version of the programme / module for the 2019/0 academic year.